This 53-day old fetus shows external hydrocephalus. The ewe was fed Veratrum californicum on Day 14 of pregnancy. The brain and skull of this early fetus were affected by cyclopamine from the young Veratrum californicum plant.
Both ewes are near term. The ewe on the left show normal mammary development and enlargement of the vulva in preparation for labor and parturition. The ewe on the right carrying a deformed fetus did not receive the fetal signal to initiate parturition.
Comparison of two sets of twins. A normal set of twin lambs is shown at the right. A set of postmature lambs with deformed skulls and brains is shown at the left. The affected fetuses continued to grow in utero but failed to initiate parturition due to a nonfunctional hypophysis, hence a failure to release ACTH. Consequently the adrenal glands did not produce cortisol to initiate parturition.
Cranial deformities due to abnormal development during the organogenesis stage, as a result of ingestion of Veratrum californicum by the dam just before or just after Day 14 of gestation. Ingestion on Day 14 would have resulted in derangement of the pituitary gland and failure by the fetus to trigger parturition at term.
Skull of a young sheep affected as an embryo by the ingestion of Veratrum californicum by its dam. The function of the hypophysis was not affected allowing the fetus to trigger its own delivery at term.
The fetus is positioned for adrenalectomy via the flank. The fetal membranes and edges of the uterine incision are sealed by clamping to the skin of the fetus to minimize loss of fetal fluids.
Experimental bilateral fetal adrenalectomy at 120-days of gestation rendered the fetus incapable of initiating parturition. The fetus continued to grow past term until delivered by cesarean section. The fetal membranes and edges of the uterine incision were sealed by clamping to minimize loss of fetal fluids.